Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2

Activates the Inflammasome via Aim2 Cutting Edge: Cytosolic Bacterial DNA

Inflammasome Cutting Edge: Necrosis Activates the NLRP3

Microbial DNA regulates intestinal homeostasis via the AIM2 inflammasome

Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which upon activation assembles a multiprotein complex called the inflammasome. Previous studies have shown that several inflammasome-forming pattern recognition receptors exhibit a protective function against inflammatory bowel disease and colorectal cancer. However, the role of AIM2 in sensing intestinal microbial DNA and regulating inflam...

Homophilic Interaction Cutting Edge: NTB-A Activates NK Cells via

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.